Sinequan is very sedating
In some cases it is used in European countries and South Asia.It was formerly recognized as “Dothiepin” in the United States.Amitriptylinoxide (Amioxid): This TCA drug hit European markets in the 1970s as a treatment for major depression.It produces similar effects to the drug Amitriptyline, which makes sense because it is a metabolite of Amitriptyline.
These days they are still used for depression, but are considered a second-line treatment to newer drugs like SSRIs/SNRIs and atypical antidepressants.
Many still consider them to be highly effective, but newer medications are typically favored by professionals and patients because they carry less side effects and are regarded as being safer.
TCAs are usually prescribed as a second-line treatment option prior to trying Monoamine Oxidase Inhibitors (MAOIs).
The list is not exhaustive and not all drugs are used regularly in all countries.
Some medications treat multiple conditions and appear multiple times.
This lead researchers to believe that it may have some antidepressant effects.