Sinequan is very sedating
Tricyclic Antidepressants (TCAs) were developed in the 1950s as a way to treat depression with chemical compounds.
These drugs are known for their specific chemical structure consisting of three rings of atoms, hence being referred to as “tri”-cyclic.
The list is not exhaustive and not all drugs are used regularly in all countries.
Some medications treat multiple conditions and appear multiple times.
Tricyclics were developed after researchers began exploring derivatives of the first typical antipsychotic medication Thorazine.
Experimentation with derivatives lead to the development of the first TCA drug called “Imipramine.”Initially the drug Imipramine was not intended to treat depressive symptoms, but it was found to induce mania.
This is a list of psychiatric medications used by psychiatrists and other physicians to treat mental illness or distress.
These days they are still used for depression, but are considered a second-line treatment to newer drugs like SSRIs/SNRIs and atypical antidepressants.
This lead to a trend of many companies developing tricyclic antidepressants with different three ring structures from Imipramine.
Tricyclic antidepressants became commonly prescribed for the treatment of major depression and were considered very effective at managing symptoms.
Many still consider them to be highly effective, but newer medications are typically favored by professionals and patients because they carry less side effects and are regarded as being safer.
TCAs are usually prescribed as a second-line treatment option prior to trying Monoamine Oxidase Inhibitors (MAOIs).Amitriptylinoxide (Amioxid): This TCA drug hit European markets in the 1970s as a treatment for major depression.It produces similar effects to the drug Amitriptyline, which makes sense because it is a metabolite of Amitriptyline.It was created by Merck and approved by the FDA for medical use in 1961.